Manufacturers / Finished Adhesives and Sealants

Self-Adhesive Sealant Film

tissuemed tissue patch csf sealant filmA new clinical study finds the use of a sealant film “encouraging” in the prevention of CSF leaks.

UK surgical sealant manufacturer Tissuemed Ltd. has announced the publication of a new clinical paper in World Neurosurgery relating to its self-adhesive dural sealant film products. Written by Paolo Ferroli, Ph.D., professor Giovanni Broggi and coworkers at the Carlo Besta Institute in Milan, the retrospective study details 119 patients who underwent elective neurosurgery. All patients received TissuePatchDural to reinforce dural closure following identification of a cerebrospinal fluid (CSF) leak after routine dural closure.

The mixed population of patients included 22 who were assessed as being high risk for reasons including previous surgery, radiotherapy, long-term corticosteroid use and hydrocephalus. Supratentorial, infratentorial and spinal patients were also included.

Overall, CSF leaks were detected in 11 of the 119 patients (9.2%), all occurring within two weeks of surgery. Patients were additionally assessed at two and six months following treatment; none were found to be suffering CSF leakage. In the 22 patients considered high risk, there was a higher percentage of CSF leaks (36.3%), compared to a 3.1% leak rate in the 97 cases without additional risk. All leaks were treated conservatively and no patient required re-admission or repeat surgery.

In conclusion, the authors commented, “In our experience, the product appears to be safe and no adverse reaction was evident throughout the study. Results in terms of CSF leak prevention are promising.”

David Mandley, Ph.D., Tissuemed CEO, said, “This latest paper, the third in 12 months published by European neurosurgeons, represents the largest patient cohort receiving TissuePatchDural to be investigated and reported to date. As we approach four years since the launch of TissuePatchDural, I’m delighted to have such positive clinical experience and published data from the Carlo Besta Institute, a highly regarded and world renowned center of excellence in the field of neurosurgery.”

The technology used in TissuePatch products is based on the in-situ bonding of synthetic polymers to bodily tissues. The products are thin, synthetic films that bond covalently to amine groups on the surface of internal tissues to provide fluid- and air-tight seals. These films are used as an adjunct to traditional suturing or stapling in a variety of surgical procedures where achieving a secure closure is paramount.

For more information, visit

Did you enjoy this article? Click here to subscribe to Adhesives & Sealants Industry Magazine.

You must login or register in order to post a comment.



Image Galleries

ASI April 2014 Photo Gallery

Our April 2014 issue is now available!


ExxonMobil Tackifier Expansion

Dwight Tozer, vice president of ExxonMobil’s Adhesion Industry business, discusses the company’s latest tackifier expansion project with Editor-in-Chief Susan Sutton.

More Podcasts

Adhesives & Sealants Industry Magazine

ASI June 2015 cover

2015 June

Welcome to our annual Dispensing & Curing Equipment Directory!
Table Of Contents Subscribe

"Cultural Fit"

A recent opinion piece in the New York Times observed that new employees are often hired based on the personal similarities they share with their interviewers. How important is “cultural fit” when hiring someone?
View Results Poll Archive


Handbook of Sealant Technology

The Handbook of Sealant Technology provides an in-depth examination of sealants, reviewing their historical developments and fundamentals, adhesion theories and properties, and today’s wide range of applications.

More Products

ASI 2014 Buyers GuideASI's Buyers' Guide

Annual purchasing resource for equipment used in the manufacture/formulation of adhesives, sealants, pressure sensitives, tapes and labels and for application of finished adhesives. 


facebook_40px twitter_40  youtube_40pxlinkedin_40 google+ icon ASI 30px

Clear Seas Research

With access to over one million professionals and more than 60 industry-specific publications, Clear Seas Research offers relevant insights from those who know your industry best. Let us customize a market research solution that exceeds your marketing goals.