Vilsmeier reagent [(chloromethylene) dimethylammonium chloride] is designed for use in dehydration, chlorination and formylation reactions. According to the company. the material can reduce byproduct formation in reactions and simplify workup.
Use of the material can reportedly eliminate the need for the user to handle highly toxic phosgene, thionyl chloride, phosphoryl chloride or oxalyl chloride to generate a reagent. The material is a stable, crystalline solid prepared from dimethylformamide (DMF) and carbonyl dichloride (phosgene).
For more information, visitwww.vdmchemical.com.
VANDEMARK: Vilsmeier Reagent
September 12, 2011